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Creating ATP via creatine kinase B for NLRP3 activation

Nature Immunology volume 23, pages 653–655 (2022)Cite this article

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A role for mitochondrial ATP that leads to phosphocreatine and the subsequent generation of cytosolic ATP via creatine kinase B is now proposed in the activation of the NLRP3 inflammasome.

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Fig. 1: Electron transport chain and the phosphocreatine shuttle contribute to NLRP3 inflammasome activation.

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Authors and Affiliations

  1. Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil

    Juliana E. Toller-Kawahisa

  2. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

    Juliana E. Toller-Kawahisa & Luke A. J. O’Neill

Authors
  1. Juliana E. Toller-Kawahisa
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  2. Luke A. J. O’Neill
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Correspondence to Luke A. J. O’Neill.

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The authors declare no competing interests.

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Toller-Kawahisa, J.E., O’Neill, L.A.J. Creating ATP via creatine kinase B for NLRP3 activation. Nat Immunol 23, 653–655 (2022). https://doi.org/10.1038/s41590-022-01191-5

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