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INKT CELLS

Macrophages make the bed for early iNKT cells

Colonization of the mucosal tissues by iNKT cells was thought to be linked to the first contact with the environment. New research demonstrates that this process is regulated by and dependent on embryonic macrophages.

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Fig. 1: Colon iNKT cell expansion in early life is dependent on embryonic macrophages.

References

  1. Lynch, L. et al. Nat. Immunol. 16, 85–95 (2015).

    Article  CAS  Google Scholar 

  2. Diana, J. et al. Immunity 30, 289–299 (2009).

    Article  CAS  Google Scholar 

  3. Crosby, C. M. & Kronenberg, M. Nat. Rev. Immunol. 18, 559–574 (2018).

    Article  CAS  Google Scholar 

  4. Gensollen, T. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-00934-0 (2021).

  5. Nieuwenhuis, E. E. S. et al. J. Clin. Invest. 119, 1241–1250 (2009).

    Article  CAS  Google Scholar 

  6. Olszak, T. et al. Science 336, 489–493 (2012).

    Article  CAS  Google Scholar 

  7. Olszak, T. et al. Nature 509, 497–502 (2014).

    Article  CAS  Google Scholar 

  8. Ginhoux, F. & Guilliams, M. Immunity 44, 439–449 (2016).

    Article  CAS  Google Scholar 

  9. Bain, C. C. et al. Nat. Immunol. 15, 929–937 (2014).

    Article  CAS  Google Scholar 

  10. Scott, C. L. et al. Nat. Commun. 7, 10321 (2016).

    Article  CAS  Google Scholar 

  11. Simoni, Y. et al. Eur. J. Immunol. 41, 3574–3585 (2011).

    Article  CAS  Google Scholar 

  12. Rubio, M.-T. et al. Blood 120, 2144–2154 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Agnès Lehuen.

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Bertrand, L., Toubal, A. & Lehuen, A. Macrophages make the bed for early iNKT cells. Nat Immunol 22, 681–682 (2021). https://doi.org/10.1038/s41590-021-00938-w

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