Impressive progress has been made over the last several years toward understanding how almost every aspect of the immune system contributes to the expression of systemic autoimmunity. In parallel, studies have shed light on the mechanisms that contribute to organ inflammation and damage. New approaches that address the complicated interaction between genetic variants, epigenetic processes, sex and the environment promise to enlighten the multitude of pathways that lead to what is clinically defined as systemic lupus erythematosus. It is expected that each patient owns a unique ‘interactome’, which will dictate specific treatment.
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I thank my colleagues current and past who have helped me acquire a better understanding of this formidable disease known as lupus. I want to thank M. Tsokos for her support and feedback during the preparation of this report and N. Plummer for helping with the assembly of references. The work in my laboratory has been supported by the NIH.
The author declares no competing interests.
Editor recognition statement L. A. Dempsey was the primary editor on this article and managed its editorial process and peer review in collaboration with the rest of the editorial team.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Tsokos, G.C. Autoimmunity and organ damage in systemic lupus erythematosus. Nat Immunol 21, 605–614 (2020). https://doi.org/10.1038/s41590-020-0677-6
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