The virome, increasingly recognized as a critical component of the mammalian microbiota, modulates host physiology. An antiviral treatment approach reveals that, via RIG-I signaling, the commensal virome is essential for the homeostasis of intestinal intraepithelial lymphocytes.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Liu, L. Nat. Immunol. https://doi.org/10.1038/s41590-019-0513-z (2019).
Belkaid, Y. & Hand, T. W. Cell 157, 121–141 (2014).
Virgin, H. W. Cell 157, 142–150 (2014).
Kernbauer, E., Ding, Y. & Cadwell, K. Nature 516, 94–98 (2014).
Ingle, H. et al. Nat. Microbiol. 4, 1120–1128 (2019).
Barton, E. S. et al. Nature 447, 326–329 (2007).
Loo, Y. M. & Gale, M. Jr. Immunity 34, 680–692 (2011).
Yang, J. Y. et al. Immunity 44, 889–900 (2016).
Krishnamurthy, S. R. & Wang, D. Virus Res. 239, 136–142 (2017).
Burgener, E. B. et al. Sci. Transl. Med. 11, eaau9748 (2019).
Sweere, J. M. et al. Science 363, eaat9691 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Lee, S., Baldridge, M.T. Viruses RIG up intestinal immunity. Nat Immunol 20, 1563–1564 (2019). https://doi.org/10.1038/s41590-019-0530-y
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-019-0530-y
This article is cited by
-
The human virome: assembly, composition and host interactions
Nature Reviews Microbiology (2021)