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Heavy metal protease takes a tiki torch to HIV assembly

The plasma membrane–associated metalloprotease TRABD2A degrades the HIV Gag polyprotein and restricts virion assembly.

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The authors declare no competing interests.

Correspondence to Una O’Doherty or Eric O. Freed.

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Fig. 1: HIV-1 replication is blocked at multiple stages in resting CD4+ T cells.