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DYSFUNCTIONAL B CELLS

Silencing of TLM B cells by chronic HIV infection

Chronic infection with human immunodeficiency virus impairs B cell antigen receptor signaling via a newly described mechanism of inhibitory signaling mediated by IgG3 and the IgG Fc receptor FcRγIIb (CD32b).

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Fig. 1: Antigen-dependent and antigen-independent suppression of BCR signaling by FcRγIIb.

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Correspondence to Raul M. Torres.

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Agazio, A.E., Pelanda, R. & Torres, R.M. Silencing of TLM B cells by chronic HIV infection. Nat Immunol 19, 902–903 (2018). https://doi.org/10.1038/s41590-018-0191-2

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