Lysosomal hyperacidification is regarded as a hallmark of autophagy. A new pH nanosensor that detects shifts in near-infrared emission bands is used to quantify cellular and intratumoral lysosomal pH.
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References
Lawrence, R. E. & Zoncu, R. Nat. Cell Biol. 21, 133–142 (2019).
Mulcahy Levy, J. M. & Thorburn, A. Cell Death Differ. 27, 843–857 (2020).
Mijin, K. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01364-9 (2023).
Hou, J. T. et al. Chem. Soc. Rev. 46, 2076–2090 (2017).
Steinegger, A., Wolfbeis, O. S. & Borisov, S. M. Chem. Rev. 120, 12357–12489 (2020).
Welsher, K., Sherlock, S. P. & Dai, H. Proc. Natl Acad. Sci. USA 108, 8943–8948 (2011).
Kwon, H. et al. J. Phys. Chem. C 119, 3733–3739 (2015).
Chen, Q. et al. Nat. Commun. 11, 6290 (2020).
Fang, H. et al. Nat. Commun. 12, 109 (2021).
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Qiu, K., Tian, Z. & Diao, J. Monitoring lysosomal acidity. Nat Chem Biol 19, 1434–1435 (2023). https://doi.org/10.1038/s41589-023-01348-9
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DOI: https://doi.org/10.1038/s41589-023-01348-9