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Shackled ribosomes unleashed

A directed evolution approach delivers ribosomes with highly functional tethered subunits. Combining the decoding and peptidyl transferase activities of the ribosome into a single entity sets the scene for more efficient protein engineering technologies.

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Fig. 1: Engineering of efficient tethered ribosomes via evolution and linkage (EvoLink).


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Correspondence to Oliver Rackham.

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Filipovska, A., Rackham, O. Shackled ribosomes unleashed. Nat Chem Biol 18, 918–920 (2022).

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