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Challenges and opportunities in controlling mosquito-borne infections

Naturevolume 559pages490497 (2018) | Download Citation

Abstract

Mosquito-borne diseases remain a major cause of morbidity and mortality across the tropical regions. Despite much progress in the control of malaria, malaria-associated morbidity remains high, whereas arboviruses—most notably dengue—are responsible for a rising burden of disease, even in middle-income countries that have almost completely eliminated malaria. Here I discuss how new interventions offer the promise of considerable future reductions in disease burden. However, I emphasize that intervention programmes need to be underpinned by rigorous trials and quantitative epidemiological analyses. Such analyses suggest that the long-term goal of elimination is more feasible for dengue than for malaria, even if malaria elimination would offer greater overall health benefit to the public.

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Acknowledgements

I thank the Medical Research Council, the National Institute of Health Research Health Protection Research Unit programme, the National Institute of General Medical Sciences ‘MIDAS’ programme and the Bill and Melinda Gates Foundation for research funding. Among many others, A. Ghani, A. Burt and S. O’Neill have informed my understanding of this topic during many illuminating discussions.

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  1. MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, UK

    • Neil M. Ferguson

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