Characteristic patterns of joint involvement exist in different forms of arthritis. Research now indicates that epigenetic programming of synovial fibroblasts diversifies their response to inflammatory cascades, leading to this anatomical variation in arthritis and its response to treatment.
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Bolton, C., Croft, A.P. All fibroblasts are equal, but some are more equal than others. Nat Rev Rheumatol 20, 254–255 (2024). https://doi.org/10.1038/s41584-024-01097-6
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DOI: https://doi.org/10.1038/s41584-024-01097-6