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IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration

Nature Reviews Rheumatology volume 19, pages 535–536 (2023)Cite this article

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IL-17 signalling regulates both protective and harmful immune responses; therefore, its complete inhibition can have adverse effects. Detailed consideration and fine-tuning of IL-17-inhibition strategies is needed to selectively regulate disease outcomes.

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Fig. 1: IL-17 signalling in joint inflammation and regeneration.

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Authors and Affiliations

  1. Department of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Iannis E. Adamopoulos

  2. Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA

    Vijay Kuchroo

  3. Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Vijay Kuchroo

Authors
  1. Iannis E. Adamopoulos
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  2. Vijay Kuchroo
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Correspondence to Iannis E. Adamopoulos.

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Competing interests

I.E.A. declares that he has received speaker fees, research support and/or served on advisory boards for Novartis, Pfizer and Merck. V.K. declares no competing interests.

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Adamopoulos, I.E., Kuchroo, V. IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration. Nat Rev Rheumatol 19, 535–536 (2023). https://doi.org/10.1038/s41584-023-01004-5

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  • DOI: https://doi.org/10.1038/s41584-023-01004-5

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