Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Vasculitis

A basket genetic trial of the vasculitides

Nature Reviews Rheumatology volume 19, pages 541–542 (2023)Cite this article

Subjects

The rarity of various forms of vasculitis, as well as other rheumatic diseases, presents difficulties in studying the genetics of these diseases as well as for evaluating treatments. Might new approaches, such as joint genetic analyses and drug repurposing, provide opportunities to learn more about these diseases and identify new therapies and serve as a basis for basket clinical trials?

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Study design and novel genes and drug repurposing candidates identified.

References

  1. Lengline, E. et al. Basket clinical trial design for targeted therapies for cancer: a French National Authority for Health statement for health technology assessment. Lancet Oncol. 22, e430–e434 (2021).

    Article  PubMed  Google Scholar 

  2. Ortiz-Fernandez, L. et al. Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing. Ann. Rheum. Dis. (2023).

  3. Lin, V. S., Xu, Z. F., Huang, D. C. S. & Thijssen, R. BH3 mimetics for the treatment of B-cell malignancies-insights and lessons from the clinic. Cancers (Basel) 12, 3353 (2020).

    Article  CAS  PubMed  Google Scholar 

  4. Morrow, G. B. & Mutch, N. J. Past, present, and future perspectives of plasminogen activator inhibitor 1 (PAI-1). Semin. Thromb. Hemost. 49, 305–313 (2023).

    Article  CAS  PubMed  Google Scholar 

  5. Nakanishi, T. et al. Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality. J. Clin. Invest. 131, e152386 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Teruel, M. et al. Integrative epigenomics in Sjogren’s syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature. Sci. Rep. 11, 23292 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Graham, R. R. et al. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat. Genet. 40, 1059–1061 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Musone, S. L. et al. Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat. Genet. 40, 1062–1064 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Barturen, G. et al. Integrative analysis reveals a molecular stratification of systemic autoimmune diseases. Arthritis Rheumatol. 73, 1073–1085 (2021).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. GENYO (Center for Genomics and Oncological Research), Pfizer-University of Granada-Andalusian Regional Government, Granada, Spain

    Elena Carnero-Montoro & Marta E. Alarcón-Riquelme

Authors
  1. Elena Carnero-Montoro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marta E. Alarcón-Riquelme
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marta E. Alarcón-Riquelme.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Carnero-Montoro, E., Alarcón-Riquelme, M.E. A basket genetic trial of the vasculitides. Nat Rev Rheumatol 19, 541–542 (2023). https://doi.org/10.1038/s41584-023-00996-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41584-023-00996-4

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing