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Linking NAD metabolism and DNA repair to inflammation in SSc

According to new data, overexpression of the nicotinamide adenine dinucleotide (NAD) hydrolase, CD38, in systemic sclerosis (SSc) leads to NAD depletion and fibrosis. These intriguing findings link inflammation, NAD metabolism and fibrosis and bare striking resemblance to age-related changes in SSc. Could DNA damage also connect these seemingly unrelated pathways?

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Fig. 1: CD38 links NAD, metabolism and DNA repair to inflammation in SSc.


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The work of E.V.A. is supported by the POR Campania FESR 2014-2020 “SATIN” grant, and the work of A.G. is supported by Fondazione di Medicina Molecolare e Terapia Cellulare (Ancona-Italy).

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Correspondence to Enrico Vittorio Avvedimento or Armando Gabrielli.

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The authors declare no competing interests.

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Avvedimento, E.V., Gabrielli, A. Linking NAD metabolism and DNA repair to inflammation in SSc. Nat Rev Rheumatol (2021).

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