The discovery that autoantibodies and other factors can predict the future onset of rheumatoid arthritis (RA) has encouraged the development of clinical trials looking at RA prevention. Although an exciting area of research, finding an approach that results in the successful completion of an RA prevention trial is challenging.
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Deane, K. D. & Holers, V. M. Rheumatoid arthritis pathogenesis, prediction, and prevention: an emerging paradigm shift. Arthritis Rheumatol. 73, 181–193 (2021).
van Boheemen, L. et al. Atorvastatin is unlikely to prevent rheumatoid arthritis in high risk individuals: results from the prematurely stopped STAtins to Prevent Rheumatoid Arthritis (STAPRA) trial. RMD Open 7, e001591 (2021).
van Boheemen, L. et al. How to enhance recruitment of individuals at risk of rheumatoid arthritis into trials aimed at prevention: understanding the barriers and facilitators. RMD Open 7, e001592 (2021).
Al-Laith, M. et al. Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol. Trials 20, 429 (2019).
Gerlag, D. M. et al. Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study. Ann. Rheum. Dis. 78, 179–185 (2019).
Holers, V. M. et al. Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction. Nat. Rev. Rheumatol. 14, 542–557 (2018).
Falahee, M. et al. Preferences of patients and at-risk individuals for preventive approaches to rheumatoid arthritis. Clin. Ther. 41, 1346–1354 (2019).
Tanner, S. et al. A prospective study of the development of inflammatory arthritis in the family members of Indigenous North American people with rheumatoid arthritis. Arthritis Rheumatol. 71, 1494–1503 (2019).
Ellerby, J. H. et al. Bioethics for clinicians: 18. Aboriginal cultures. CMAJ 163, 845–850 (2000).
Gerlag, D. M. et al. EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis. Ann. Rheum. Dis. 71, 638–641 (2012).
The authors declare no competing interests.
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O’Neil, L.J., Deane, K.D. Striking a balance in rheumatoid arthritis prevention trials. Nat Rev Rheumatol (2021). https://doi.org/10.1038/s41584-021-00627-w