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RHEUMATOID ARTHRITIS

Does methotrexate improve TNF inhibitor drug survival in elderly patients with RA?

Nature Reviews Rheumatology volume 16, pages 353–354 (2020)Cite this article

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Methotrexate is commonly used in combination with biologic DMARDs in the treatment of rheumatoid arthritis on the basis that the combined therapy has synergistic benefits. New data challenge this concept in the treatment of older adults and highlight the uncertainty of the mode of action of methotrexate in this population.

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Authors and Affiliations

  1. Service de gériatrie, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France

    Clément Lahaye

  2. Université Clermont Auvergne, Institut national de recherche pour l’agriculture, l’alimentation et l’environnement, Unité de Nutrition Humaine, Centre de Recherches en Nutrition Humaine d’Auvergne, Clermont-Ferrand, France

    Clément Lahaye

  3. Service de Rhumatologie, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France

    Martin Soubrier

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  1. Clément Lahaye
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  2. Martin Soubrier
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Correspondence to Martin Soubrier.

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The authors declare no competing interests.

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Lahaye, C., Soubrier, M. Does methotrexate improve TNF inhibitor drug survival in elderly patients with RA?. Nat Rev Rheumatol 16, 353–354 (2020). https://doi.org/10.1038/s41584-020-0411-7

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