The ability to predict how a patient might respond to a medication would shift treatment decisions away from trial and error and reduce disease-associated health and financial burdens. Machine learning approaches applied to genomic datasets offer great promise to deliver personalized medicine but their application must first be optimized.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Tao, W. et al. Multi-omics and machine learning accurately predicts clinical response to adalimumab and etanercept therapy in patients with rheumatoid arthritis. Arthritis Rheumatol. https://doi.org/10.1002/art.41516 (2020).
National Center for Biotechnology Information. Gene expression omnibus database https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE138747 (2020).
Riley, R. D. et al. Minimum sample size for developing a multivariable prediction model: PART II - binary and time-to-event outcomes. Stat. Med. 38, 1276–1296 (2019).
Guyon, I. & Elisseeff, A. An introduction to variable and feature selection. J. Mach. Learn. Res. 3, 157–1182 (2003).
Ball, T. M. et al. Double dipping in machine learning: problems and solutions. Biol. Psychiatry Cogn. Neurosci. Neuroimaging 5, 261–263 (2020).
Tasaki, S. et al. Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission. Nat. Commun. 9, 2755 (2018).
Ritchie, M. D. et al. Methods of integrating data to uncover genotype-phenotype interactions. Nat. Rev. Genet. 16, 85–97 (2015).
Zhu, B. et al. Integrating clinical and multiple omics data for prognostic assessment across human cancers. Sci. Rep. 7, 16954 (2017).
Acknowledgements
The work of D.P. and A.B. is supported by the National Institute for Health Research (NIHR) Manchester Biomedical Research Centre and by the Versus Arthritis Centre for Genetics and Genomics. A.B. is an NIHR Senior Investigator.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Disclaimer
The views expressed in this article are those of the authors and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health.
Rights and permissions
About this article
Cite this article
Plant, D., Barton, A. Machine learning in precision medicine: lessons to learn. Nat Rev Rheumatol 17, 5–6 (2021). https://doi.org/10.1038/s41584-020-00538-2
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41584-020-00538-2
This article is cited by
-
An introduction to machine learning and analysis of its use in rheumatic diseases
Nature Reviews Rheumatology (2021)