How to improve care for patients with RA and comorbidities

Comorbidities are highly prevalent in patients with rheumatoid arthritis (RA), yet clinical care for such patients is often of inferior quality, even in rheumatology clinics. Suggestions for good clinical practice interventions from an expert panel aim to improve the quality of care for patients with RA who have associated comorbidities.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Radner, H. et al. Multimorbidity and rheumatic conditions–enhancing the concept of comorbidity. Nat. Rev. Rheumatol. 10, 252–256 (2014).

    Article  Google Scholar 

  2. 2.

    Radner, H. et al. Treatment patterns of multimorbid patients with rheumatoid arthritis: Results from an international cross-sectional study. J. Rheumatol. 42, 1099–1104 (2015).

    CAS  Article  Google Scholar 

  3. 3.

    Luque Ramos, A. et al. Comorbidities in patients with rheumatoid arthritis and their association with patient-reported outcomes: Results of claims data linked to questionnaire survey. J. Rheumatol. 46, 564–571 (2019).

    Article  Google Scholar 

  4. 4.

    Kvien, T. K. et al. Considerations for improving quality of care of patients with rheumatoid arthritis and associated comorbidities. RMD Open 6, e001211 (2020).

    Article  Google Scholar 

  5. 5.

    Yoshida, K. et al. The roles of post-diagnosis accumulation of morbidities and lifestyle changes on excess total and cause-specific mortality risk in rheumatoid arthritis. Arthritis Care Res. https://doi.org/10.1002/acr.24120 (2019).

    Article  Google Scholar 

  6. 6.

    Radner, H., Smolen, J. S. & Aletaha, D. Impact of comorbidity on physical function in patients with rheumatoid arthritis. Ann. Rheum. Dis. 69, 536–541 (2009).

    Article  Google Scholar 

  7. 7.

    Radner, H. et al. The impact of multimorbidity status on treatment response in rheumatoid arthritis patients initiating disease-modifying anti-rheumatic drugs. Rheumatology 54, 2076–2084 (2015).

    CAS  Article  Google Scholar 

  8. 8.

    Agca, R. et al. EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. Ann. Rheum. Dis. 76, 17–28 (2017).

    CAS  Article  Google Scholar 

  9. 9.

    Baillet, A. et al. Points to consider for reporting, screening for and preventing selected comorbidities in chronic inflammatory rheumatic diseases in daily practice: a EULAR initiative. Ann. Rheum. Dis. 75, 965–973 (2016).

    Article  Google Scholar 

  10. 10.

    Calderon-Larranaga, A. et al. Multimorbidity and functional impairment-bidirectional interplay, synergistic effects and common pathways. J. Intern. Med. 285, 255–271 (2019).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Helga Radner.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Radner, H. How to improve care for patients with RA and comorbidities. Nat Rev Rheumatol 16, 607–608 (2020). https://doi.org/10.1038/s41584-020-00504-y

Download citation


Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing