Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

AUTOIMMUNITY

Do IL-7 R+ innate cells orchestrate autoimmune pathology?

Nature Reviews Rheumatology volume 15, pages 640–642 (2019)Cite this article

Subjects

Immunopathology in autoimmune diseases is promoted by complex interactions between many types of immune cells, and adequate disease inhibition relies on targeting molecules that orchestrate these interactions. One such molecule, IL-7, has well-known effects on lymphoid cells, but could this cytokine also affect innate immune cells to induce immunopathology?

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: IL-7 R+ innate cells in rheumatic autoimmune diseases promote immunopathology.

References

  1. Bikker, A. Interleukin-7: a key mediator in T cell-driven autoimmunity, inflammation, and tissue destruction. Curr. Pharm. Des. 18, 2347–2356 (2012).

    CAS  PubMed  Google Scholar 

  2. Kim, S. J. et al. Macrophages are the primary effector cells in IL-7-induced arthritis. Cell. Mol. Immunol. https://doi.org/10.1038/s41423-019-0235-z (2019).

    Article  PubMed  Google Scholar 

  3. Chen, Z. The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis. J. Immunol. 190, 5256–5266 (2013).

    Article  CAS  Google Scholar 

  4. Gary-Gouy, H., Lebon, P. & Dalloul, A. H. Type I interferon production by plasmacytoid dendritic cells and monocytes is triggered by viruses, but the level of production is controlled by distinct cytokines. J. Interferon Cytokine Res. 22, 653–659 (2002).

    Article  CAS  Google Scholar 

  5. Castellanos, J. G. & Longman, R. S. The balance of power: innate lymphoid cells in tissue inflammation and repair. J. Clin. Invest. 130, 2640–2650 (2019).

    Article  Google Scholar 

  6. Moret, F. M. et al. The efficacy of abatacept in reducing synovial T cell activation by CD1c myeloid dendritic cells is overruled by the stimulatory effects of T cell-activating cytokines. Arthritis Rheumatol. 67, 637–644 (2015).

    Article  CAS  Google Scholar 

  7. Blokland, S. L. M. et al. Increased CCL25 and T helper cells expressing CCR9 in the salivary glands of patients with primary Sjögren’s syndrome: potential new axis in lymphoid neogenesis. Arthritis Rheumatol. 69, 2038–2051 (2017).

    Article  CAS  Google Scholar 

  8. Gracey, E. et al. IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis. Ann. Rheum. Dis. 75, 2124–2132 (2016).

    Article  CAS  Google Scholar 

  9. Zhou, V. et al. A colitogenic memory CD4+ T cell population mediates gastrointestinal graft-versus-host disease. J. Clin. Invest. 126, 3541–3555 (2016).

    Article  Google Scholar 

  10. Duurland, C. L. et al. CD161+ Tconv and CD161+ Treg share a transcriptional and functional phenotype despite limited overlap in TCRβ repertoire. Front. Immunol. 8, 103 (2017).

    Article  Google Scholar 

Download references

Acknowledgements

The work of A.C.H. is supported financially by ReumaNederland.

Author information

Authors and Affiliations

  1. Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

    Anneline C. Hinrichs & Joel A. G. van Roon

  2. Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

    Anneline C. Hinrichs & Joel A. G. van Roon

Authors
  1. Anneline C. Hinrichs
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joel A. G. van Roon
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Joel A. G. van Roon.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hinrichs, A.C., van Roon, J.A.G. Do IL-7 R+ innate cells orchestrate autoimmune pathology?. Nat Rev Rheumatol 15, 640–642 (2019). https://doi.org/10.1038/s41584-019-0297-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41584-019-0297-4

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing