Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

RHEUMATOID ARTHRITIS

Characterizing the autoreactive B cell transcriptome

Nature Reviews Rheumatology volume 15, pages 132–133 (2019)Cite this article

Subjects

Autoantibodies have been recognized and studied for decades, but evaluation of the cellular and molecular processes underlying autoantibody production has until now been fairly limited. Can the use of cutting-edge technology to isolate autoreactive B cells and characterize their transcriptional activity provide further insight?

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Clavel, C. et al. Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen. Arthritis Rheum. 58, 678–688 (2008).

    Article  CAS  Google Scholar 

  2. Sokolove, J. et al. Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcgamma receptor. Arthritis Rheum. 63, 53–62 (2011).

    Article  CAS  Google Scholar 

  3. Harre, U. et al. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J. Clin. Invest. 122, 1791–1802 (2012).

    Article  CAS  Google Scholar 

  4. Kuhn, K. A. et al. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J. Clin. Invest. 116, 961–973 (2006).

    Article  CAS  Google Scholar 

  5. Ho, P. P. et al. Autoimmunity against fibrinogen mediates inflammatory arthritis in mice. J. Immunol. 184, 379–390 (2010).

    Article  CAS  Google Scholar 

  6. Sohn, D. H. et al. Local Joint inflammation and histone citrullination in a murine model of the transition from preclinical autoimmunity to inflammatory arthritis. Arthritis Rheumatol. 67, 2877–2887 (2015).

    Article  CAS  Google Scholar 

  7. Zendman, A. J., Vossenaar, E. R. & van Venrooij, W. J. Autoantibodies to citrullinated (poly)peptides: a key diagnostic and prognostic marker for rheumatoid arthritis. Autoimmunity 37, 295–299 (2004).

    Article  CAS  Google Scholar 

  8. Mahendra, A. et al. Beyond autoantibodies: biological roles of human autoreactive B cells in rheumatoid arthritis revealed by RNA-sequencing. Arthritis Rheumatol. https://doi.org/10.1002/art.40772 (2018).

  9. Benito-Miguel, M. et al. IL-15 Expression on RA synovial fibroblasts promotes B cell survival. PLOS ONE 7, e40620 (2012).

    Article  CAS  Google Scholar 

  10. Swanson, C. D. et al. Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis. J. Immunol. 188, 3513–3521 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Immunology and Rheumatology, VA Palo Alto Healthcare System and Stanford University School of Medicine, Stanford, CA, USA

    Jeremy Sokolove

Authors
  1. Jeremy Sokolove
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jeremy Sokolove.

Ethics declarations

Competing interests

The author declares that he is an employee of AbbVie. The views expressed in this publication are his own and do not represent those of his current employer.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sokolove, J. Characterizing the autoreactive B cell transcriptome. Nat Rev Rheumatol 15, 132–133 (2019). https://doi.org/10.1038/s41584-019-0169-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41584-019-0169-y

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing