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CELL BIOLOGY

Gasdermin D opens the way for NETs

Nature Reviews Rheumatology volume 14, pages 690–692 (2018)Cite this article

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Gasdermin D is a pore-forming protein that can cause pyroptosis, a form of inflammatory cell death. New research indicates that the pores generated by gasdermin D can also promote the formation of neutrophil extracellular traps, potentially opening new therapeutic avenues for the treatment of inflammatory diseases.

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Fig. 1: Function of gasdermin D in neutrophils.

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Authors and Affiliations

  1. Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

    Lotte Spel & Fabio Martinon

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  1. Lotte Spel
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  2. Fabio Martinon
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Correspondence to Fabio Martinon.

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The authors declare no competing interests.

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Spel, L., Martinon, F. Gasdermin D opens the way for NETs. Nat Rev Rheumatol 14, 690–692 (2018). https://doi.org/10.1038/s41584-018-0124-3

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