OSTEOARTHRITIS

A Notch in the joint that exacerbates osteoarthritis

Tight regulation of signalling cascades is vital for the correct development and function of bones and joints. A new study suggests that Notch signalling might join the likes of the transforming growth factor superfamily and Wnt signalling cascades as having an important function in joint homeostasis and disease.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Monteagudo, S. & Lories, R. J. Cushioning the cartilage: a canonical Wnt restricting matter. Nat. Rev. Rheumatol. 13, 670–681 (2017).

    CAS  Article  Google Scholar 

  2. 2.

    van der Kraan, P. M. The changing role of TGFbeta in healthy, ageing and osteoarthritic joints. Nat. Rev. Rheumatol. 13, 155–163 (2017).

    Article  Google Scholar 

  3. 3.

    Siebel, C. & Lendahl, U. Notch signaling in development, tissue homeostasis, and disease. Physiol. Rev. 97, 1235–1294 (2017).

    CAS  Article  Google Scholar 

  4. 4.

    Zanotti, S. et al. Mice harboring a Hajdu Cheney Syndrome mutation are sensitized to osteoarthritis. Bone 114, 198–205 (2018).

    CAS  Article  Google Scholar 

  5. 5.

    Canalis, E. Clinical and experimental aspects of notch receptor signaling: Hajdu-Cheney syndrome and related disorders. Metabolism 80, 48–56 (2018).

    CAS  Article  Google Scholar 

  6. 6.

    Kohn, A. et al. Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development. Development 139, 1198–1212 (2012).

    CAS  Article  Google Scholar 

  7. 7.

    Hosaka, Y. et al. Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development. Proc. Natl Acad. Sci. USA 110, 1875–1880 (2013).

    CAS  Article  Google Scholar 

  8. 8.

    Liu, Z. et al. Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance. Osteoarthritis Cartilage 24, 740–751 (2016).

    CAS  Article  Google Scholar 

  9. 9.

    Liu, Z. et al. A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci. Signal. 8, ra71 (2015).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  10. 10.

    Mirando, A. J. et al. RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. Arthritis Rheum. 65, 2623–2633 (2013).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The work of the authors is supported by Excellence of Science Grant “Join-t-against-OA”, grants from the Flanders Research Foundation (FWO Vlaanderen), a C1 grant from KU Leuven and an unrestricted grant from Celgene to S.M.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Rik J. Lories.

Ethics declarations

Competing interests

R.J.L. declares that Leuven Research and Development, the technology transfer office of KU Leuven, has received consultancy and speakers fees from Galapagos and Samumed on his behalf. S.M. declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Monteagudo, S., Lories, R.J. A Notch in the joint that exacerbates osteoarthritis. Nat Rev Rheumatol 14, 563–564 (2018). https://doi.org/10.1038/s41584-018-0076-7

Download citation

Further reading

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing