Rapid eye movement (REM) sleep is often considered to be a global brain state. Here, electroencephalogram recordings during human REM sleep revealed two independent, spatially separate clusters of slow, delta-frequency waves: fronto-central ‘sawtooth’ waves that occurred during eye movements, and slower medial-occipital waves, similar to those seen during non-REM sleep. Thus, delta waves are a feature of REM sleep, and REM sleep is a spatiotemporally heterogeneous brain state.
Bernardi, G. et al. Regional delta waves in human rapid-eye movement sleep. J. Neurosci. https://doi.org/10.1523/JNEUROSCI.2298-18.2019 (2019)
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Bray, N. REM sleep makes slow waves. Nat Rev Neurosci 20, 191 (2019). https://doi.org/10.1038/s41583-019-0146-0