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GENOME ORGANIZATION

The makeup of a nuclear subcompartment

Nature Reviews Molecular Cell Biology volume 21, pages 304–305 (2020)Cite this article

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The use of chromatin conformation capture techniques such as Hi-C has revealed that large scale genome organization involves the segregation of loci into gene-active (euchromatin) or gene-inactive (heterochromatin) compartments. Both compartments can be divided into subcompartments, the physical organization of which is unclear. Rosencrance et al. now show that megabases (Mb)-long domains on different chromosomes interact and form nuclear subcompartments.

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Original article

  • Rosencrance, C. D. et al. Chromatin hyperacetylation impacts chromosome folding by forming a nuclear subcompartment. Mol. Cell 78, 112–126 (2020)

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  1. Nature Reviews Molecular Cell Biology http://www.nature.com/nrm/

    Eytan Zlotorynski

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  1. Eytan Zlotorynski
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Correspondence to Eytan Zlotorynski.

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Zlotorynski, E. The makeup of a nuclear subcompartment. Nat Rev Mol Cell Biol 21, 304–305 (2020). https://doi.org/10.1038/s41580-020-0245-9

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  • DOI: https://doi.org/10.1038/s41580-020-0245-9

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