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The honeybee microbiota and its impact on health and disease

Nature Reviews Microbiology volume 22, pages 122–137 (2024)Cite this article

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Abstract

Honeybees (Apis mellifera) are key pollinators that support global agriculture and are long-established models for developmental and behavioural research. Recently, they have emerged as models for studying gut microbial communities. Earlier research established that hindguts of adult worker bees harbour a conserved set of host-restricted bacterial species, each showing extensive strain variation. These bacteria can be cultured axenically and introduced to gnotobiotic hosts, and some have basic genetic tools available. In this Review, we explore the most recent research showing how the microbiota establishes itself in the gut and impacts bee biology and health. Microbiota members occupy specific niches within the gut where they interact with each other and the host. They engage in cross-feeding and antagonistic interactions, which likely contribute to the stability of the community and prevent pathogen invasion. An intact gut microbiota provides protection against diverse pathogens and parasites and contributes to the processing of refractory components of the pollen coat and dietary toxins. Absence or disruption of the microbiota results in altered expression of genes that underlie immunity, metabolism, behaviour and development. In the field, such disruption by agrochemicals may negatively impact bees. These findings demonstrate a key developmental and protective role of the microbiota, with broad implications for bee health.

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Fig. 1: Microbial dynamics and spatial organization in the honeybee gut.
Fig. 2: The roles of the honeybee gut microbiota in pathogen protection.
Fig. 3: The roles of the honeybee gut microbiota in development and behaviour.
Fig. 4: The roles of the honeybee gut microbiota in digestion and detoxification.
Fig. 5: Beekeeping and agricultural practices that affect honeybee gut communities.

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Acknowledgements

This work was supported by the US NIH (award R35GM131738) and the USDA National Institute of Food and Agriculture (award 2018-67013-27540) to N.A.M.

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    Erick V. S. Motta & Nancy A. Moran

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N.A.M. is an author on a patent application (US20220152128A1) for using native bee gut bacteria as bee probiotics. E.V.S.M. declares no competing interests.

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Motta, E.V.S., Moran, N.A. The honeybee microbiota and its impact on health and disease. Nat Rev Microbiol 22, 122–137 (2024). https://doi.org/10.1038/s41579-023-00990-3

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