FUNGAL PATHOGENESIS

Slipping through the NET

Candida auris recently emerged as a serious fungal pathogen that can cause invasive candidasis with mortality rates as high as 60%; however, little is known about the pathogenesis of C. auris and it is unclear why it is spreading rapidly in hospitals. In a recent study, Johnson et al. investigated the interaction between C. auris and neutrophils, which control invasive candidasis through phagocytosis or by releasing neutrophil extracellular traps (NETs). In a co-culture in vitro system, human neutrophils were poorly recruited and killed C. auris at lower levels compared to Candida albicans. Moreover, these neutrophils failed to form NETs. When neutrophils were mixed with both C. auris and C. albicans, neutrophils preferentially interacted with and killed C. albicans. When these Candida species were injected into zebrafish larvae hindbrains, ~50% fewer neutrophils were recruited to C. auris, and NETs were only produced in the presence of C. albicans, suggesting that the evasion of neutrophils contributes to the virulence of C. auris.

References

Original article

  1. Johnson, C. J. et al. Emerging fungal pathogen Candida auris evades neutrophil attack. mBio 9, e01403 (2018)

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Ashley York.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

York, A. Slipping through the NET. Nat Rev Microbiol 16, 583 (2018). https://doi.org/10.1038/s41579-018-0084-2

Download citation

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing