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Nomenclature of HBV core protein-targeting antivirals

Hepatitis B virus (HBV) core protein-targeting compounds are in or entering clinical development without a standardized nomenclature. We propose a naming convention for these core-targeting antiviral products to provide clarity and accelerate HBV drug development.

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Fig. 1: Mode of action of CAMs supporting the proposed nomenclature.

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Correspondence to Fabien Zoulim.

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Competing interests

F.Z. has received grants from Assembly Biosciences, Beam, Janssen and Viravaxx and is also a consultant for Assembly, Aligos, Antios, Arbutus, Gilead Sciences, GlaxoSmithKline, Janssen and Vir Biotechnology. A.Z. has equity in Assembly Biosciences and serves on their scientific advisory board. A.Z. is also a founder and Chief Scientific Officer of Door Pharmaceutical. J.F. is an employee of Aligos Therapeutics. A.G. is a former employee and current stakeholder of Gilead Sciences. J.H. has been supported by funding from the National Institute of Allergy and Infectious Disease/NIH and Gilead for work relevant here and has consulted for Arbutus, Bristol Myers Squibb, Gilead, Janssen, Roche and Sanofi. O.L. is an employee of Janssen and is a shareholder of Johnson & Johnson. N.M. is an employee of Arbutus Biopharma. W.D. is an employee at Assembly Biosciences and owns stock in Assembly Biosciences and Gilead. S.W. has received funding from Gilead. V.M. receives grant funding for the HBV Forum from Abbott, Aligos Therapeutis, Altimmune, Antios Therapeutics, Assembly Biosciences, Enanta Pharma, Enyo Pharma, Gilead, GlaxoSmithKline, Immunocore, Janssen, Monogram Biosciences, Quest Diagnostics, RFS Family Foundation, Roche, VenatorX, Vir Biotechnology and Virion. H.L.A.J. has received grants from AbbVie, Gilead, GlaxoSmithKline, Janssen, Roche and Vir Biotechnology, and is also a consultant for Aligos, Antios, Arbutus, Eiger, Gilead Sciences, GlaxoSmithKline, Janssen, Merck, Roche, VBI Vaccines, Vir Biotechnology and Viroclinics. S.B., E.D., M.K., K.L., M.N. and G.W. declare no competing interests.

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Zoulim, F., Zlotnick, A., Buchholz, S. et al. Nomenclature of HBV core protein-targeting antivirals. Nat Rev Gastroenterol Hepatol 19, 748–750 (2022). https://doi.org/10.1038/s41575-022-00700-z

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