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Gut bacteria go on record

Microbiota profiling using stool samples is limited in its ability to represent intestinal microbial dynamics. CRISPR-engineered bacteria can be used to acquire cellular RNAs and create a gene expression ‘memory’ during gastrointestinal transit, with the potential to capture microbial transcriptomic changes in the gastrointestinal tract without invasive sampling.

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Fig. 1: Experimental use cases of Record-seq in the gut microbiome.


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Correspondence to Jotham Suez.

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Crits-Christoph, A., Suez, J. Gut bacteria go on record. Nat Rev Gastroenterol Hepatol 19, 557–558 (2022).

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