Although available clinical outcome data are reassuring, the consequences of in utero exposure to inflammatory bowel disease (IBD) pharmacotherapies on the development of the neonatal immune system remain ill-defined. So too does the converse effect on immunological maturation of fetal exposure to maternal inflammatory activity. Both warrant elucidation to appropriately stratify antenatal IBD care.
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Acknowledgements
R.E.P. is funded by an Australian Government Research Training Program Scholarship. C.A.N.-P. is funded by an NHMRC Investigator Grant Leadership 1 (grant 1173584). The authors were also supported by the Victorian State Government Operational Infrastructure Scheme. M.F.N. is funded by the Fielding Fellowship 2017 by the Fielding Foundation.
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Prentice, R.E., Bell, S.J., Nold-Petry, C.A. et al. Safety of in utero exposure to maternal IBD pharmacotherapies. Nat Rev Gastroenterol Hepatol 19, 213–214 (2022). https://doi.org/10.1038/s41575-021-00572-9
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DOI: https://doi.org/10.1038/s41575-021-00572-9