Colorectal cancer screening has a large potential to reduce incidence and mortality, and screening programmes have been implemented in many countries and regions. Emerging epidemiological trends and evidence on the effectiveness and cost-effectiveness of various screening options call for regular updates of screening recommendations.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
US Preventive Services Task Force. Screening for colorectal cancer: US Preventive Services Task Force Recommendation Statement. JAMA 325, 1965–1977 (2021).
Siegel, R. L. et al. Colorectal cancer statistics, 2020. CA Cancer J. Clin. 70, 145–164 (2020).
Jeon, J. et al. Determining risk of colorectal cancer and starting age of screening based on lifestyle, environmental, and genetic factors. Gastroenterology 154, 2152–2164 (2018).
Peterse, E. F. P. et al. Comparing the cost-effectiveness of innovative colorectal cancer screening tests. J. Natl Cancer Inst. 113, 154–161 (2021).
Brenner, H., Stock, C. & Hoffmeister, M. In the era of widespread endoscopy use, randomized trials may strongly underestimate the effects of colorectal cancer screening. J. Clin. Epidemiol. 66, 1144–1150 (2013).
Shaukat, A. et al. Long-term mortality after screening for colorectal cancer. N. Engl. J. Med. 369, 1106–1114 (2013).
Brenner, H., Stock, C. & Hoffmeister, M. Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies. BMJ 348, g2467 (2014).
Buskermolen, M. et al. Colorectal cancer screening with faecal immunochemical testing, sigmoidoscopy or colonoscopy: a microsimulation modelling study. BMJ 367, l5383 (2019).
Gies, A., Cuk, K., Schrotz-King, P. & Brenner, H. Direct comparison of diagnostic performance of 9 quantitative fecal immunochemical tests for colorectal cancer screening. Gastroenterology 154, 93–104 (2018).
Gruner, L. F. et al. The effects of different invitation schemes on the use of fecal occult blood tests for colorectal cancer screening: systematic review of randomized controlled trials. Cancers 13, 1520 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Brenner, H., Hoffmeister, M. Striving to optimize colorectal cancer prevention. Nat Rev Gastroenterol Hepatol 18, 677–678 (2021). https://doi.org/10.1038/s41575-021-00494-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41575-021-00494-6