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Endocrine–exocrine signals in obesity-associated pancreatic cancer

Obesity is a known risk factor for pancreatic cancer. Now, a new study reports that obesity accelerates early pancreatic cancer development and growth in mice through local perturbations in the pancreatic microenvironment and implicates pancreatic islet-derived cholecystokinin as a driving factor.

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The laboratory of the author is supported by the National Cancer Institute (P01CA236585).

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Correspondence to Guido Eibl.

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The author declares no competing interests.

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Eibl, G. Endocrine–exocrine signals in obesity-associated pancreatic cancer. Nat Rev Gastroenterol Hepatol 17, 455–456 (2020).

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