Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

STEM CELLS

A new model of intestinal epithelial regeneration: could patients benefit?

Nature Reviews Gastroenterology & Hepatology volume 17, pages 137–138 (2020)Cite this article

Subjects

A new study has identified an intestinal stem cell population involved in epithelial regeneration upon injury in mice and provided an in vitro tool with which to characterize the recurrent damage–repair mechanisms affecting chronic gastrointestinal inflammatory disorders, including inflammatory bowel disease.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Applications of a novel model to investigate intestinal epithelial regeneration.

References

  1. Planell, N. et al. Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations. Gut 62, 967–976 (2013).

    Article  CAS  Google Scholar 

  2. Dotti, I. et al. Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis. Gut 66, 2069–2079 (2017).

    Article  CAS  Google Scholar 

  3. Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262–265 (2009).

    Article  CAS  Google Scholar 

  4. Jung, P. et al. Isolation and in vitro expansion of human colonic stem cells. Nat. Med. 17, 1225–1227 (2011).

    Article  CAS  Google Scholar 

  5. Wang, Y. et al. Long-term culture captures injury-repair cycles of colonic stem cells. Cell 179, 1144–1159 (2019).

    Article  CAS  Google Scholar 

  6. Gehart, H. & Clevers, H. Tales from the crypt: new insights into intestinal stem cells. Nat. Rev. Gastroenterol. Hepatol. 16, 19–34 (2019).

    Article  Google Scholar 

  7. Feakins, R. M. & British Society of Gastroenterology. Inflammatory bowel disease biopsies: updated British Society of Gastroenterology reporting guidelines. J. Clin. Pathol. 66, 1005–1026 (2013).

    Article  Google Scholar 

  8. Smillie, C. S. et al. Intra- and inter-cellular rewiring of the human colon during ulcerative colitis. Cell 178, 714–730 (2019).

    Article  CAS  Google Scholar 

  9. Parikh, K. et al. Colonic epithelial cell diversity in health and inflammatory bowel disease. Nature 567, 49–55 (2019).

    Article  CAS  Google Scholar 

  10. Usui, T. et al. Preparation of human primary colon tissue-derived organoid using air liquid interface culture. Curr. Protoc. Toxicol. 75, 22.6.1–22.6.7 (2018).

    Article  Google Scholar 

Download references

Acknowledgements

The authors thank J. Moore for English-language editorial assistance. I.D. is funded by the Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020), Grant 720905. A.S. is funded by the Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) and Grant RTI2018-096946-B-I00 from the Ministerio de Ciencia, Innovación y Universidades, Spain.

Author information

Authors and Affiliations

  1. Inflammatory Bowel Disease Unit, Department of Gastroenterology, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) – CIBEREHD, Barcelona, Spain

    Isabella Dotti & Azucena Salas

Authors
  1. Isabella Dotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Azucena Salas
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Azucena Salas.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dotti, I., Salas, A. A new model of intestinal epithelial regeneration: could patients benefit?. Nat Rev Gastroenterol Hepatol 17, 137–138 (2020). https://doi.org/10.1038/s41575-020-0267-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41575-020-0267-y

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing