A new study sheds further light on the interplay between environmental stimuli, the gut microbiota and intestinal inflammation. Identification of modifiable environmental triggers and the mechanisms by which they act has implications for the prevention and treatment of inflammatory bowel disease.
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References
de Lange, K. M. et al. Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. Nat. Genet. 49, 256–261 (2017).
Devkota, S. et al. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. Nature 487, 104–108 (2012).
Lee, J.-Y. et al. High-fat diet and antibiotics cooperatively impair mitochondrial bioenergetics to trigger dysbiosis that exacerbates pre-inflammatory bowel disease. Cell Host Microbe 28, 273–284 (2020).
Torres, J. et al. Serum biomarkers identify patients who will develop inflammatory bowel diseases up to 5 years before diagnosis. Gastroenterology 159, 96–104 (2020).
Piovani, D. et al. Environmental risk factors for inflammatory bowel diseases: an umbrella review of meta-analyses. Gastroenterology 157, 647–659 (2019).
Al Nabhani, Z. et al. Excess calorie intake early in life increases susceptibility to colitis in adulthood. Nat. Metab. 1, 1101–1109 (2019).
Rousseaux, C. et al. Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J. Exp. Med. 201, 1205–1215 (2005).
Byndloss, M. X. et al. Microbiota-activated PPAR-γ-signaling inhibits dysbiotic Enterobacteriaceae expansion. Science 357, 570–575 (2017).
Colombel, J.-F. et al. Effect of tight control management on Crohn’s disease (CALM): a multicentre, randomised, controlled phase 3 trial. Lancet 390, 2779–2789 (2018).
Fritsch, J. et al. Low-Fat, High-fiber diet reduces markers of inflammation and dysbiosis and improves quality of life in patients with ulcerative colitis. Clin. Gastroenterol. Hepatol. https://doi.org/10.1016/j.cgh.2020.05.026 (2020).
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C.L. is funded by a UKRI Future Leaders Fellowship and has received additional research support from AbbVie, Chief Scientist’s Office, Cure Crohn’s Colitis and Gilead. He has received consultancy fees from AbbVie, Dr Falk, Gilead, Hospira, Iterative Scopes, Janssen, Oshi Health, Pfizer, Takeda, Trellus Health and Vifor Pharma. He has received speaking fees and travel support from AbbVie, Dr. Falk, Ferring, Gilead, Hospira, Janssen, Pfizer and Takeda.
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Lees, C.W. Environmental stimuli and gut inflammation via dysbiosis in mouse and man. Nat Rev Gastroenterol Hepatol 17, 715–716 (2020). https://doi.org/10.1038/s41575-020-00373-6
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DOI: https://doi.org/10.1038/s41575-020-00373-6