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Searching for superstool: maximizing the therapeutic potential of FMT

Faecal microbiota transplantation (FMT), a highly effective treatment for Clostridium difficile infection, is now being explored for complex diseases, but innovative trial design and collaborative approaches are essential for unlocking its therapeutic potential. If ‘superstool’ capable of treating a complex disease exists, then FMT trials should aim to find and use it.

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Fig. 1: Model of donor stool heterogeneity in treating complex diseases.

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Correspondence to Stacy A. Kahn.

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Olesen, S.W., Leier, M.M., Alm, E.J. et al. Searching for superstool: maximizing the therapeutic potential of FMT. Nat Rev Gastroenterol Hepatol 15, 387–388 (2018). https://doi.org/10.1038/s41575-018-0019-4

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