NEUROGASTROENTEROLOGY

Crohn’s and Parkinson disease: is LRRK2 lurking around the corner?

Exome sequencing of patients with Crohn’s disease (CD) of Ashkenazi Jewish descent and genotyping of large case–control cohorts has identified new CD risk and protective variants of LRRK2, the most common genetic determinant of Parkinson disease. These findings provide new insights into the pathophysiology of these two seemingly unrelated disorders.

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Fig. 1: Variants of LRRK2 associated with risk of Crohn’s disease and Parkinson disease.

References

  1. 1.

    Derkinderen, P. et al. Parkinson disease: the enteric nervous system spills its guts. Neurology 77, 1761–1767 (2011).

    Article  PubMed  CAS  Google Scholar 

  2. 2.

    Bialecka, M. et al. CARD15 variants in patients with sporadic Parkinson’s disease. Neurosci. Res. 57, 473–476 (2007).

    Article  PubMed  CAS  Google Scholar 

  3. 3.

    Liu, J. Z. et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat. Genet. 47, 979–986 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. 4.

    Hui, K. Y. et al. Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease. Sci Transl Med. 10, eaai7795 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Moehle, M. S. et al. LRRK2 inhibition attenuates microglial inflammatory responses. J. Neurosci. 32, 1602–1611 (2012).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. 6.

    Liu, Z. et al. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat. Immunol. 12, 1063–1070 (2011).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. 7.

    Lin, J. C. et al. Association between Parkinson’s disease and inflammatory bowel disease: a nationwide Taiwanese retrospective cohort Study. Inflamm. Bowel Dis. 22, 1049–1055 (2016).

    Article  PubMed  Google Scholar 

  8. 8.

    Fujioka, S. et al. Occurrence of crohn’s disease with Parkinson’s disease. Parkinsonism Relat. Disord. 37, 116–117 (2017).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors acknowledge the part funding of their research on Parkinson’s disease by Comité d’entente et de coordination des associations de Parkinsoniens (CECAP), France Parkinson et Parkinsoniens de Vendée.

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Correspondence to Pascal Derkinderen.

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The authors declare no competing interests.

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Derkinderen, P., Neunlist, M. Crohn’s and Parkinson disease: is LRRK2 lurking around the corner?. Nat Rev Gastroenterol Hepatol 15, 330–331 (2018). https://doi.org/10.1038/s41575-018-0006-9

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