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Seeing through the fog: a neuroendocrine explanation for post-COVID cognitive deficits

Nature Reviews Endocrinology volume 20, pages 189–190 (2024)Cite this article

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Gonadotropin-releasing hormone is implicated in cognitive functions, and its loss is a factor in pathological brain ageing. There are similarities between these processes and the neurological and cognitive deficits observed in patients with long COVID. Here, we explore the hypothesis that neuroanatomical and transcriptomic alterations associated with long COVID could stem from this neuroendocrine perturbation.

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Acknowledgements

The authors acknowledge the support of the European Research Council ERC-Synergy-Grant-2019-WATCH No. 810331 (to R.N., V. P. and M.S.), the Agence Nationale de la Recherche en Santé et la Fondation pour la Recherche Médicale (No. ECTZ200878 Long Covid 2021 ANRS0167 SIGNAL to V.P., M.S. and R.N.) and the European Union Horizon 2020 research and innovation program No. 847941 miniNO (to V.P.).

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Authors and Affiliations

  1. University of Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, FHU 1000 days for health Lille, Lille, France

    S. Rasika & Vincent Prevot

  2. CIMUS, Universidade de Santiago de Compostela, Santiago de Compostela, Spain

    Ruben Nogueiras

  3. Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany

    Markus Schwaninger

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  1. S. Rasika
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  2. Ruben Nogueiras
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  4. Vincent Prevot
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Correspondence to S. Rasika, Ruben Nogueiras, Markus Schwaninger or Vincent Prevot.

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Rasika, S., Nogueiras, R., Schwaninger, M. et al. Seeing through the fog: a neuroendocrine explanation for post-COVID cognitive deficits. Nat Rev Endocrinol 20, 189–190 (2024). https://doi.org/10.1038/s41574-024-00955-3

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