Adipocytes have high levels of many components of the complement system. These components are involved in antimicrobial activities, but also have the potential to regulate the maintenance and turn-over of adipocytes under normal and pathophysiological conditions through positive and negative regulation of the membrane attack complex.
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The authors were supported by US National Institutes of Health Grants R01-DK55758, R01-DK127274, R01-DK131537, R01-DK099110, P01-AG051459 and RC2-DK118620 (to P.E.S).
The authors declare no competing interests.
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Kruglikov, I.L., Scherer, P.E. Control of adipose tissue cellularity by the terminal complement cascade. Nat Rev Endocrinol 19, 679–680 (2023). https://doi.org/10.1038/s41574-023-00900-w