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Large study on hormone therapy for transgender youth provides reassurance amid treatment politicization

Findings from the largest longitudinal study (315 participants) on psychosocial functioning in transgender or nonbinary youth after 2 years of gender-affirming hormone (GAH) therapy were recently published in New England Journal of Medicine. At a time of heightened politicization of this treatment, this study adds to the growing literature that demonstrates benefits of GAH therapy for transgender youth.

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References

  1. Chen, D. et al. Psychosocial functioning in transgender youth after 2 years of hormones. N. Engl. J. Med. 388, 240–250 (2023).

    Article  CAS  PubMed  Google Scholar 

  2. Hembree, W. C. et al. Endocrine treatment of gender-dysphoric/gender-incongruent persons: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 102, 3869–3903 (2017).

    Article  PubMed  Google Scholar 

  3. Coleman, E. et al. Standards of care for the health of transgender and gender diverse people, version 8. Int. J. Transgender Health 23 (Suppl 1), S1–S259 (2022).

    Article  CAS  Google Scholar 

  4. American Civil Liberties Union. Mapping attacks on LBGTQ rights in the US state legislature. aclu.org, https://www.aclu.org/legislative-attacks-on-lgbtq-rights (2023).

  5. de Vries, A. L. et al. Young adult psychological outcome after puberty suppression and gender reassignment. Pediatrics 134, 696–704 (2014).

    Article  PubMed  Google Scholar 

  6. Tordoff, D. M. et al. Mental health outcomes in transgender and nonbinary youths receiving gender-affirming care. JAMA Netw. Open 5, e220978 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Kuper, L. E., Stewart, S., Preston, S., Lau, M. & Lopez, X. Body dissatisfaction and mental health outcomes of youth on gender-affirming hormone therapy. Pediatrics 145, e20193006 (2020).

    Article  PubMed  Google Scholar 

  8. Cohen-Kettenis, P. T. & van Goozen, S. H. Pubertal delay as an aid in diagnosis and treatment of a transsexual adolescent. Eur. Child Adolesc. Psychiatry 7, 246–248 (1998).

    Article  CAS  PubMed  Google Scholar 

  9. Arnoldussen, M. et al. Re-evaluation of the Dutch approach: are recently referred transgender youth different compared to earlier referrals? Eur. Child Adolesc. Psychiatry 29, 803–811 (2020).

    Article  PubMed  Google Scholar 

  10. The Trevor Project. 2022 National survey on LGBTQ youth mental health. thetrevorproject.org, https://www.thetrevorproject.org/survey-2022 (2022).

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Correspondence to Ximena Lopez.

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Lopez, X., Kuper, L.E. Large study on hormone therapy for transgender youth provides reassurance amid treatment politicization. Nat Rev Endocrinol 19, 319–320 (2023). https://doi.org/10.1038/s41574-023-00824-5

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