The long non-coding RNA HOTAIR is exclusively expressed in gluteofemoral subcutaneous adipose tissue (GSAT) and is functionally required for GSAT adipocyte differentiation. A genetic variation analysis showed that the minor allele of rs1443512 is associated with reduced HOTAIR expression and decreased adipose tissue mass in the leg and gynoid regions.
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Xu, D., Sun, L. HOTAIR underlies the region-specific development of adipose tissue. Nat Rev Endocrinol 18, 663–664 (2022). https://doi.org/10.1038/s41574-022-00754-8
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DOI: https://doi.org/10.1038/s41574-022-00754-8
