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PITUITARY GLAND

The human pituitary master gland stripped to single-cell resolution

Stem cells in the pituitary master gland remain mystifying; moreover, they have hardly been explored in humans. A new study applied transcriptome and chromatin accessibility profiling at single-cell resolution to human postmortem pituitary glands from individuals of different ages, thereby providing insights into the heterogeneity and regulatory mechanisms of the projected human pituitary stem cell population.

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Fig. 1: Setup and considerations of the human pituitary single-nucleus profiling study.

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Acknowledgements

We thank L. Hemeryck (KU Leuven, Belgium) for her help in creating the first version of the figure.

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Correspondence to Hugo Vankelecom.

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The authors declare no competing interests.

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Interactive web portal: http://snpituitaryatlas.princeton.edu/

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Laporte, E., Vankelecom, H. The human pituitary master gland stripped to single-cell resolution. Nat Rev Endocrinol 18, 395–396 (2022). https://doi.org/10.1038/s41574-022-00696-1

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