A new paper reports that the protein isthmin 1 is secreted by mature adipocytes and triggers a signalling cascade similar to that of insulin. The novel adipokine acts through an unidentified receptor tyrosine kinase and, at pharmacological doses in mice, isthmin 1 ameliorates metabolic disturbances associated with type 2 diabetes mellitus, including hyperglycaemia and liver steatosis.
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Serum levels of the novel adipokine isthmin-1 are associated with obesity in pubertal boys
World Journal of Pediatrics Open Access 03 January 2023
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Heeren, J., Scheja, L. Isthmin 1 — a novel insulin-like adipokine. Nat Rev Endocrinol 17, 709–710 (2021). https://doi.org/10.1038/s41574-021-00569-z
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DOI: https://doi.org/10.1038/s41574-021-00569-z
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Serum levels of the novel adipokine isthmin-1 are associated with obesity in pubertal boys
World Journal of Pediatrics (2023)
