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REPRODUCTIVE ENDOCRINOLOGY

Relugolix — new treatment for uterine fibroid-related heavy bleeding

Limited pharmacological treatments for uterine leiomyomata (fibroids) are available. Now, two phase III trials lasting 24 weeks showed marked reduction in leiomyoma-related heavy menstrual bleeding with relugolix, a new orally active gonadotropin-releasing hormone antagonist with add-back oestrogen (to limit bone loss) and progestin (to limit endometrial changes from unopposed oestrogen).

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Fig. 1: Pharmacological options associated with fibroid development and symptoms.

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Acknowledgements

The authors thank L. Wyrick and T. Winslow for assistance with figure creation and A. Wilcox for reviewing the figure format. E. Myers read and commented on an earlier version of the text. The authors also acknowledge the support of the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences.

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Correspondence to Donna D. Baird.

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Baird, D.D., Harmon, Q.E. Relugolix — new treatment for uterine fibroid-related heavy bleeding. Nat Rev Endocrinol 17, 321–322 (2021). https://doi.org/10.1038/s41574-021-00493-2

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