A new way to ignite thermogenesis in human adipose tissue

Thermogenic adipose tissue is a metabolic sink for excess fuel and is a promising target for the treatment of obesity and type 2 diabetes mellitus. However, hurdles exist in activating thermogenic adipose tissue in humans. A new study developed a drug screening platform utilizing human beige adipose tissue and identified non-canonical activators.

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Fig. 1: Adipose-derived stem cell pipeline for metabolic treatment.


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Correspondence to Shingo Kajimura.

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The authors declare no competing interests.

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Verkerke, A.R.P., Kajimura, S. A new way to ignite thermogenesis in human adipose tissue. Nat Rev Endocrinol 16, 475–476 (2020).

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