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Human sperm RNA code senses dietary sugar

A new study reveals that a high-sugar diet acutely alters human sperm small RNA profiles after 1 week and that these changes are associated with changes in sperm motility. This rapid response by sperm to nutritional fluctuation raises intriguing questions regarding the underlying mechanisms and the potential effects on offspring metabolic health.

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Fig. 1: Potential modulation of sperm by high-sugar diet.


  1. 1.

    Zhang, Y., Shi, J., Rassoulzadegan, M., Tuorto, F. & Chen, Q. Sperm RNA code programmes the metabolic health of offspring. Nat. Rev. Endocrinol. 15, 489–498 (2019).

    Article  Google Scholar 

  2. 2.

    Chen, Q. et al. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science 351, 397–400 (2016).

    CAS  Article  Google Scholar 

  3. 3.

    Zhang, Y. et al. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nat. Cell Biol. 20, 535–5402 (2018).

    CAS  Article  Google Scholar 

  4. 4.

    Sharma, U. et al. Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science 351, 391–396 (2016).

    CAS  Article  Google Scholar 

  5. 5.

    Nätt, D. et al. Human sperm displays rapid responses to diet. PLoS Biol. 17, e3000559 (2019).

    Article  Google Scholar 

  6. 6.

    Schimmel, P. The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis. Nat. Rev. Mol. Cell Biol. 19, 45–58 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Brownlee, M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54, 1615–1625 (2005).

    CAS  Article  Google Scholar 

  8. 8.

    Thompson, D. M. & Parker, R. Stressing out over tRNA cleavage. Cell 138, 215–219 (2009).

    CAS  Article  Google Scholar 

  9. 9.

    Hayakawa, H. et al. Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine. Biochemistry 41, 12739–12744 (2002).

    Article  Google Scholar 

  10. 10.

    Donkin, I. et al. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell. Metab. 23, 369–378 (2016).

    CAS  Article  Google Scholar 

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The authors thank Xudong Zhang for discussion. Y.Z. is supported by MOST (2019YFA0802600 and 2018YFC1004500) and Q.C. is supported by NIH (R01HD092431).

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Correspondence to Ying Zhang or Qi Chen.

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The authors declare no competing interests.

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Zhang, Y., Chen, Q. Human sperm RNA code senses dietary sugar. Nat Rev Endocrinol 16, 200–201 (2020).

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