A new study reveals that a high-sugar diet acutely alters human sperm small RNA profiles after 1 week and that these changes are associated with changes in sperm motility. This rapid response by sperm to nutritional fluctuation raises intriguing questions regarding the underlying mechanisms and the potential effects on offspring metabolic health.
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Zhang, Y., Shi, J., Rassoulzadegan, M., Tuorto, F. & Chen, Q. Sperm RNA code programmes the metabolic health of offspring. Nat. Rev. Endocrinol. 15, 489–498 (2019).
Chen, Q. et al. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science 351, 397–400 (2016).
Zhang, Y. et al. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nat. Cell Biol. 20, 535–5402 (2018).
Sharma, U. et al. Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science 351, 391–396 (2016).
Nätt, D. et al. Human sperm displays rapid responses to diet. PLoS Biol. 17, e3000559 (2019).
Schimmel, P. The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis. Nat. Rev. Mol. Cell Biol. 19, 45–58 (2018).
Brownlee, M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54, 1615–1625 (2005).
Thompson, D. M. & Parker, R. Stressing out over tRNA cleavage. Cell 138, 215–219 (2009).
Hayakawa, H. et al. Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine. Biochemistry 41, 12739–12744 (2002).
Donkin, I. et al. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell. Metab. 23, 369–378 (2016).
The authors thank Xudong Zhang for discussion. Y.Z. is supported by MOST (2019YFA0802600 and 2018YFC1004500) and Q.C. is supported by NIH (R01HD092431).
The authors declare no competing interests.
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Zhang, Y., Chen, Q. Human sperm RNA code senses dietary sugar. Nat Rev Endocrinol 16, 200–201 (2020). https://doi.org/10.1038/s41574-020-0331-2
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