Exercise is the elixir of health. However, timing can boost or blunt exercise performance and health benefits. Two complementary studies used transcriptomic and metabolomic tools to dissect how time of day affects the impact of exercise. The findings open new avenues for optimizing timing of physical activity to boost its benefits further.
Subscribe to Journal
Get full journal access for 1 year
only $17.42 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Gabriel, B. M. & Zierath, J. R. Circadian rhythms and exercise — re-setting the clock in metabolic disease. Nat. Rev. Endocrinol. 15, 197–206 (2019).
Burke, L. M. & Hawley, J. A. Swifter, higher, stronger: what’s on the menu? Science 362, 781–787 (2018).
Sato, S. et al. Time of exercise specifies the impact on muscle metabolic pathways and systemic energy homeostasis. Cell Metab. https://doi.org/10.1016/j.cmet.2019.03.013 (2019).
Ezagouri, S. et al. Physiological and molecular dissection of daily variance in exercise capacity. Cell Metab. https://doi.org/10.1016/j.cmet.2019.03.012 (2019).
Sullivan, J. E. et al. Characterisation of 5′-AMP-activated protein kinase in human liver using specific peptide substrates and the effects of 5′-AMP analogues on enzyme activity. Biochem. Biophys. Res. Commun. 200, 1551–1556 (1994).
Narkar, V. A. et al. AMPK and PPARdelta agonists are exercise mimetics. Cell 134, 405–415 (2008).
Hatori, M. & Panda, S. The emerging roles of melanopsin in behavioral adaptation to light. Trends Mol. Med. 16, 435–446 (2010).
Savikj, M. et al. Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial. Diabetologia 62, 233–237 (2019).
Chaix, A. et al. Time-restricted feeding prevents obesity and metabolic syndrome in mice lacking a circadian clock. Cell Metab. 29, 303–319 (2019).
Hawley, J. A. et al. Maximizing cellular adaptation to endurance exercise in skeletal muscle. Cell Metab. 27, 962–976 (2018).
Research in the Panda Lab is supported by the NIH (DK115214 and EY 016807), the Department of Homeland Security (EMW-2016-FP-00788) and the Department of Defense (W81XWH1810645). A.C. is supported by the American Heart Association (18CDA34110292).
S.P. authored “The Circadian Code” for which he collects author royalty. A.C. declares no competing interests.
About this article
Cite this article
Chaix, A., Panda, S. Timing tweaks exercise. Nat Rev Endocrinol 15, 440–441 (2019). https://doi.org/10.1038/s41574-019-0229-z
Current Hypertension Reports (2020)
New Horizons: Circadian Control of Metabolism Offers Novel Insight Into the Cause and Treatment of Metabolic Diseases
The Journal of Clinical Endocrinology & Metabolism (2020)