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Topical glucocorticoids and risk of type 2 diabetes mellitus

Nature Reviews Endocrinology (2019) | Download Citation

A positive association between topical corticosteroid use and risk of type 2 diabetes mellitus has been reported in a large European population-based study. However, the increase in risk is small and should not influence the prescribing of topical corticosteroids when clinically indicated.

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  1. 1.

    National Institute for Health and Care Excellence. Clinical knowledge summaries. Corticosteroids — oral. NICE!scenarioRecommendation:3 (2017).

  2. 2.

    Andersen, Y. M. F. et al. Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts. Diabetes Care (2019).

  3. 3.

    Reynolds, R. M. et al. Glucocorticoid treatment and impaired mood, memory and metabolism in people with diabetes: the Edinburgh Type 2 Diabetes Study. Eur. J. Endocrinol. 166, 861–868 (2012).

  4. 4.

    Krejci-Manwaring, J. et al. Adherence with topical treatment is poor compared with adherence with oral agents: implications for effective clinical use of topical agents. J. Am. Acad. Dermatol. 54, S235–S236 (2006).

  5. 5.

    Lin, L.-K. et al. Medication adherence and glycemic control among newly diagnosed diabetes patients. BMJ Open Diabetes Res. Care 5, e000429 (2017).

  6. 6.

    Donnelly, L. A., Morris, A. D. & Evans, J. M. M. Adherence to insulin and its association with glycaemic control in patients with type 2 diabetes. QJM 100, 345–350 (2007).

  7. 7.

    Leong, A. et al. Estimating the population prevalence of diagnosed and undiagnosed diabetes. Diabetes Care 36, 3002–3008 (2013).

  8. 8.

    Geer, E. B., Islam, J. & Buettner, C. Mechanisms of glucocorticoid-induced insulin resistance. Endocrinol. Metab. Clin. North Am. 43, 75–102 (2014).

  9. 9.

    Hengge, U. R. et al. Adverse effects of topical glucocorticosteroids. J. Am. Acad. Dermatol. 54, 1–15 (2006).

  10. 10.

    Milyani, A. A. & Al-Agha, A. E. Implication of topical steroids in the onset of osteoporosis. Case Rep. Pediatr. 2018, 4802172 (2018).

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  1. Tommy’s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

    • E. C. Johns
    •  & R. M. Reynolds
  2. BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

    • R. M. Reynolds


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Correspondence to R. M. Reynolds.

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