Novel osteoanabolic strategies are highly desired to treat osteoporotic bone loss or augment fracture repair in patients at risk of healing complications, including individuals with osteoporosis or inflammatory disorders. Whereas current osteoanabolics address osteoblast function, research by Ren Xu and colleagues highlights the skeletal endothelium as a promising target to promote bone formation.
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A.I. and J.T. receive funding from the German Research Foundation (Collaborative Research Center CRC1149, A.I.: INST 40/491-1, J.T.: INST 40/492-1).
The authors declare no competing interests.
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Ignatius, A., Tuckermann, J. New horizons for osteoanabolic treatment?. Nat Rev Endocrinol 14, 508–509 (2018). https://doi.org/10.1038/s41574-018-0069-2
Nature Reviews Rheumatology (2021)