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DIABETES

Amino acids — lifesaver or killer in patients with diabetes?

Distinct circulating amino acids are suggested to modulate the risk of complications and mortality related to diabetes mellitus. These findings pave the way for future basic and clinical studies to gain new insights into the pathogenesis and treatment of diabetes mellitus.

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Fig. 1: The role of circulating amino acid levels for cellular function.

References

  1. 1.

    Gancheva, S., Jelenik, T., Alvarez-Hernandez, E. & Roden, M. Interorgan metabolic crosstalk in human insulin resistance. Physiol. Rev. 98, 1371–1415 (2018).

    Article  PubMed  Google Scholar 

  2. 2.

    Welsh, P. et al. Circulating amino acids and the risk of macrovascular, microvascular and mortality outcomes in individuals with type 2 diabetes: results from the ADVANCE trial. Diabetologia 61, 1581–1591 (2018).

    Article  PubMed  CAS  Google Scholar 

  3. 3.

    Wang, T. J. et al. Metabolite profiles and the risk of developing diabetes. Nat. Med. 17, 448–453 (2011).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. 4.

    Ruiz-Canela, M. et al. Comprehensive metabolomic profiling and incident cardiovascular disease: a systematic review. J. Am. Heart Assoc. 6, e005705 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  5. 5.

    McGarrah, R. W., Crown, S. B., Zhang, G. F., Shah, S. H. & Newgard, C. B. Cardiovascular metabolomics. Circul. Res. 122, 1238–1258 (2018).

    Article  CAS  Google Scholar 

  6. 6.

    Shin, A. C. et al. Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. Cell Metab. 20, 898–909 (2014).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. 7.

    Krebs, M. et al. Mechanism of amino acid-induced skeletal muscle insulin resistance in humans. Diabetes 51, 599–605 (2002).

    Article  PubMed  CAS  Google Scholar 

  8. 8.

    Kahl, S. et al. Amino acid and fatty acid levels affect hepatic phosphorus metabolite content in metabolically healthy humans. J. Clin. Endocrinol. Metab. 103, 460–468 (2018).

    Article  PubMed  Google Scholar 

  9. 9.

    Morgan, H. E. et al. Regulation of protein synthesis in heart muscle. I. Effect of amino acid levels on protein synthesis. J. Biol. Chem. 246, 2152–2162 (1971).

    PubMed  CAS  Google Scholar 

  10. 10.

    Alshehry, Z. H. et al. Plasma lipidomic profiles improve on traditional risk factors for the prediction of cardiovascular events in type 2 diabetes mellitus. Circulation 134, 1637–1650 (2016).

    Article  PubMed  CAS  Google Scholar 

Download references

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Correspondence to Michael Roden.

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Kahl, S., Roden, M. Amino acids — lifesaver or killer in patients with diabetes?. Nat Rev Endocrinol 14, 449–451 (2018). https://doi.org/10.1038/s41574-018-0055-8

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