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Imaging

Bubbles clear the way for imaging

Ultrasound-induced gas bubbles in tissue can temporarily minimize optical scattering, enabling laser light to be focused at greater depth for higher-resolution imaging.

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Fig. 1: Principles of ultrasound-induced optical clearing microscopy (US-OCM).

References

  1. Mertz, J. Introduction to Optical Microscopy 2nd edn (Cambridge Univ. Press, 2019).

  2. Kim, H. et al. Nat. Photon. https://doi.org/10.1038/s41566-022-01068-x (2022).

  3. Wang, T. & Xu, C. Optica 7, 947–960 (2020).

    Article  ADS  Google Scholar 

  4. Gigan, S. et al. J. Phys. Photon. 4, 042501 (2022).

    Article  Google Scholar 

  5. Yu, T., Zhu, J., Li, D. & Zhu, D. iScience 24, 102178 (2021).

    Article  ADS  Google Scholar 

  6. Kim, H. & Chang, J. H. Sci. Rep. 7, 16105 (2017).

    Article  ADS  Google Scholar 

  7. Bader, K. B., Vlaisavljevich, E. & Maxwell, A. D. Ultrasound Med. Biol. 45, 1056–1080 (2019).

    Article  Google Scholar 

Download references

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Correspondence to Paul Beard or Kishan Dholakia.

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Beard, P., Dholakia, K. Bubbles clear the way for imaging. Nat. Photon. 16, 747–748 (2022). https://doi.org/10.1038/s41566-022-01091-y

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