Influenza viruses undergo rapid antigenic evolution. Analysis of a large dataset of influenza virus sequences, using host age as a proxy for immune experience, shows no evidence for immune positive selection driving antigenic evolution in individual infected humans.
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Rolfes, M. A. et al. Estimated Influenza Illnesses, Medical Visits, Hospitalizations, and Deaths Averted by Vaccination in the United States (Centers for Disease Control and Prevention, 2016).
Han, A. X., Maurer-Stroh, S. & Russell, C. A. Nat. Ecol. Evol. https://doi.org/10.1038/s41559-018-0741-x (2018).
Koel, B. F. et al. Science 342, 976–979 (2013).
Rambaut, A. et al. Nature 453, 615–619 (2008).
Bedford, T. et al. Nature 523, 217–220 (2015).
Dinis, J. M. et al. J. Virol. 90, 3355–3365 (2016).
Debbink, K. et al. PLoS Pathog. 13, e1006194 (2017).
Hensley, S. E. et al. Science 326, 734–736 (2009).
McCrone, J. T. et al. eLife 7, e35962 (2018).
Xue, K. S. et al. eLife 6, e26875 (2017).
Davis, A. K. F. et al. J. Virol. 92, e00859-18 (2018).
The authors declare no competing interests.
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Braun, K.M., Friedrich, T.C. Influenza evolution with little host selection. Nat Ecol Evol 3, 159–160 (2019). https://doi.org/10.1038/s41559-018-0782-1