A protein-templated selection approach has been developed for the discovery of full ligands from dual-pharmacophore DNA-encoded libraries by incorporating fragment linking into the selection process. The performance of this method was demonstrated with selections against protein–protein interaction and protein–DNA interaction targets, through which potent and selective inhibitors were identified.
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References
Peterson, A. A. & Liu, D. R. Small-molecule discovery through DNA-encoded libraries. Nat. Rev. Drug Discov. 22, 699–722 (2023). A review article that presents a comprehensive overview of DELs.
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This is a summary of: Zhou, Y. et al. Protein-templated ligand discovery via the selection of DNA-encoded dynamic libraries. Nat. Chem. https://doi.org/10.1038/s41557-024-01442-y (2024).
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A protein-templated selection approach for the identification of full ligands from DNA-encoded libraries. Nat. Chem. 16, 487–488 (2024). https://doi.org/10.1038/s41557-024-01441-z
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DOI: https://doi.org/10.1038/s41557-024-01441-z
